CTS includes the following standard safety features: six airbags, including side-impact airbags for the front seats and side curtain airbags for both rows; electronic stability system with traction control; four-wheel-disc antilock brakes.
| Standard Specs and Dimensions |
| Four-wheel ABS brakes | Standard |
| 4 ABS channels | Standard |
| Brake assist | Standard |
| Four-wheel disc brakes | Standard |
| Front and rear ventilated disc brakes | Standard |
| Daytime running lights | Standard |
| Compact spare tire | Available |
| Spare tire mounted inside under cargo | Available |
| Driver and passenger front-impact airbags | Standard |
| Seat-mounted driver and passenger side-impact airbags | Standard |
| Curtain 1st and 2nd row overhead airbag | Standard |
| Front passenger airbag occupancy sensor | Standard |
| Height adjustable front seatbelts | Standard |
| Front seatbelt pre-tensioners | Standard |
| 3 point rear center seatbelt | Standard |
| Side-impact bars | Standard |
| Remote activated perimeter/approach lights | Standard |
| Rear child safety locks | Standard |
| Ignition disable | PASS-Key III+ |
| Panic alarm | Standard |
| Tracker system | Standard |
| Stability control | StabiliTrak |
| ABS and driveline traction control | Standard |
| Manual adjustable front head restraints | Standard |
| Anti-whiplash front head restraints | Standard |
| 2 rear head restraints | Standard |
